Vaginal PRP & PRF Injections in NYC
Physician-Administered Platelet-Rich Fibrin for the G-Spot, Clitoris, and Labia
A Medical Approach to Sexual Wellness
Regenerative Platelet Therapy — Performed by a Board-Certified Dermatologist
Medically reviewed by Arash Akhavan, MD, FAAD | Board-Certified Dermatologist | Founder, The Dermatology and Laser Group, New York City | Faculty, Mount Sinai Department of Dermatology
Last Medically Reviewed: March 21, 2026
Vaginal PRP and PRF injections use your body's own concentrated platelets to stimulate tissue regeneration in three distinct anatomical targets: the G-Spot, the clitoris, and the labia majora. The procedure takes roughly 30 minutes, requires no general anesthesia, and involves zero downtime.
At The Dermatology and Laser Group on Manhattan's Upper East Side, Dr. Arash Akhavan performs every vaginal PRF injection personally. This is not a treatment delegated to a nurse or physician assistant. The distinction matters — accurate injection placement into the anterior vaginal wall, the clitoral complex, or the labial tissue demands a physician who understands both the anatomy and the regenerative biology at work.
What most patients search for as "vaginal PRP" is actually performed here using PRF — platelet-rich fibrin — which represents a meaningful clinical advancement over standard PRP. We made the switch from PRP to PRF over 5 years ago. The difference is not marketing. PRF eliminates the anticoagulant additives used in traditional PRP processing, which allows platelets to form a three-dimensional fibrin scaffold at the injection site. That scaffold holds 8–10 times the growth factor concentration of conventional PRP and releases those growth factors gradually over 7 to 15 days, rather than dissipating within hours. The result is a stronger, longer-lasting regenerative response in the treated tissue.
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How Vaginal PRP and PRF Actually Works
The science behind vaginal PRF injections is the same regenerative biology that orthopedic surgeons and oral surgeons have relied on for over two decades — and that we use for skin rejuvenation and promoting hair growth — adapted for gynecological tissue.
Here is what happens at the cellular level: a small blood draw is processed in a specialized centrifuge without any chemical anticoagulants. The resulting PRF concentrate contains a dense mesh of fibrin, platelets, white blood cells, and stem cell cytokines — essentially a biological scaffold your body recognizes as its own.
Once injected, that scaffold does three things:
- Recruits stem cells to the injection site through platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) signaling
- Stimulates new collagen synthesis, which increases tissue thickness and elasticity
- Promotes neovascularization — the growth of new blood vessels — which improves sensitivity and hydration in the treated area
A 2019 study published in the Journal of Cosmetic Dermatology found that PRP injections in vaginal tissue produced statistically significant improvements in mucosal thickness and self-reported sexual satisfaction at 12 weeks post-treatment. The PRF protocol used at The Dermatology and Laser Group builds on these findings with a higher growth factor payload and a sustained-release delivery mechanism.
"When I explain this procedure to patients, I compare it to fertilizing a garden," says Arash Akhavan, MD. "You are not adding anything artificial. You are concentrating what your body already produces and placing it exactly where the tissue needs regeneration. The fibrin scaffold is what makes PRF different — it holds those growth factors in place long enough for real structural change to occur."
We recommend a series of four treatments, one month apart. Results typically last approximately 12 months, and many patients return for maintenance treatments more frequently to sustain their results.
A note on terminology: This procedure is sometimes marketed at other practices as the "O-Shot" — a branded term that Dr. Arash Akhavan does not use because it trivializes what is a genuine medical procedure backed by real regenerative science. The clinical technique is the same concept, but our practice uses PRF rather than standard PRP and every injection is performed by a board-certified dermatologist.
Three Anatomical Targets, Three Different Goals
Vaginal PRF is not a single procedure — it is a framework for treating three anatomically distinct areas, each with its own clinical rationale. Arash Akhavan, MD, FAAD, tailors the injection protocol to each patient’s specific concerns during the consultation.
G-Spot PRF Injection. The G-Spot — a region of dense nerve endings on the anterior vaginal wall approximately 2–3 centimeters inside the vaginal opening — responds to PRF by thickening and becoming more sensitive. Patients who report difficulty with vaginal orgasm or reduced sensation during intercourse are often candidates for this injection. The PRF is placed using a small-gauge needle with topical and local anesthesia, and the entire injection takes under five minutes.
Clitoral PRF Injection. The clitoris contains over 8,000 nerve endings, more than any other structure in the human body. PRF injections into the clitoral complex stimulate neovascularization and tissue regeneration in this highly innervated area. Patients seeking enhanced clitoral sensitivity or improved arousal response are candidates for this injection site.
Labia Majora PRF Injection. Volume loss in the labia majora is an extremely common concern — particularly after childbirth, weight fluctuation, or with natural aging. PRF injections into the labia majora restore fullness and improve skin quality from the inside out, without synthetic fillers. This approach, sometimes called the Vampire Wing Lift by other practices, uses the same regenerative PRF concentrate to plump deflated labial tissue and improve skin texture. The results look and feel natural because the volume comes from your body’s own collagen production, not an injectable gel.
Some patients choose a single target area. Others combine two or all three in the same visit. There is no additional downtime when combining injection sites.
What Patients Experience Before, During, and After Treatment
Before Your Appointment
No special preparation is required. Patients should be well-hydrated on the day of treatment, as hydration improves the quality of the blood draw and the resulting PRF concentrate. There is no need to fast, stop other medications, or arrange for transportation home afterward.
During the Procedure
A topical numbing cream is applied to the treatment area approximately 20 minutes before injection. Pro-Nox (a self-administered blend of nitrous oxide and oxygen) is also always available if desired for all of our procedures to ensure your comfort throughout. A small blood draw is taken from the arm — the same process as a standard lab test. The blood is processed in a centrifuge for approximately 10 minutes to separate the PRF concentrate. Dr. Arash Akhavan then injects the PRF into the target area or areas using a fine-gauge needle. The injection itself takes less than five minutes per site. Total appointment time is approximately 30 minutes, including numbing and processing.
After Treatment
Patients leave the office immediately and can return to normal daily activities the same day. Mild swelling or tenderness at the injection site may occur for 24–48 hours. This is a normal part of the regenerative response. Sexual activity can typically be resumed within 24–48 hours, though Dr. Akhavan provides individualized aftercare instructions during the appointment. Initial improvements in sensitivity and tissue quality appear within 3–4 weeks. Full collagen remodeling results develop over 2–3 months.
“I tell my patients that the first few weeks are about biology doing its job beneath the surface,” says Dr. Arash Akhavan. “You will not wake up the next day feeling dramatically different. What happens is gradual — new collagen, new blood vessels, thicker tissue — and by the two-month mark, patients consistently tell me the change is unmistakable.”
Vaginal PRP Cost & Treatment Packages
The cost of vaginal PRP and PRF injections at The Dermatology and Laser Group in New York City depends on the number of anatomical areas treated and whether the patient opts for a single session or a treatment series.
A single vaginal PRF injection session is $850. For patients who want a full treatment course — which Dr. Arash Akhavan recommends for optimal collagen remodeling and sustained results — a package of four sessions is available for $3,060 (a 10% savings over individual pricing). Sessions in a package are typically spaced four to six weeks apart.
These prices apply regardless of whether the patient is treating one anatomical area (G-Spot, clitoris, or labia majora) or combining multiple sites in the same visit. There is no upcharge for treating additional areas during the same session.
Every treatment is performed personally by Arash Akhavan, MD, FAAD — a board-certified dermatologist and nationally recognized expert in cosmetic procedures. This is not a med spa service performed by a technician under indirect supervision.
Patient Testimonials and Reviews
Understanding the Science: PRF Versus Traditional PRP
PRF (platelet-rich fibrin) and PRP (platelet-rich plasma) both use the patient’s own blood to promote tissue regeneration, but they differ in processing, composition, and clinical performance. The table below compares the two technologies based on published research and the protocol used at The Dermatology and Laser Group.
| Feature | PRF (Platelet-Rich Fibrin) | PRP (Platelet-Rich Plasma) |
|---|---|---|
| Anticoagulant Additives | None | Required (citrate-based) |
| Growth Factor Level | 8–10x baseline | 2–5x baseline |
| Release Duration | 7–15 days (sustained) | Hours (rapid burst) |
| Fibrin Scaffold | Yes (3D matrix) | No |
| White Blood Cells | Retained (immune support) | Partially removed |
| Processing Time | ~10 minutes | ~15 minutes |
| Injection Frequency | 1–3 sessions | 3–6 sessions typical |
| Result Onset | 3–4 weeks | 4–8 weeks |
| Result Duration | 12–18 months | 6–12 months |
Frequently Asked Questions About Vaginal PRP & PRF
PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) both use your own blood to stimulate tissue regeneration, but PRF is a second-generation advancement. The key difference is processing: PRP uses chemical anticoagulants that prevent clotting but also limit growth factor retention, while PRF is processed without additives, allowing platelets to form a natural fibrin scaffold. That scaffold concentrates growth factors at 8–10 times the level of standard PRP and releases them gradually over 7–15 days rather than hours. At The Dermatology and Laser Group, Dr. Arash Akhavan exclusively uses PRF for vaginal rejuvenation because of this superior regenerative profile.
Most patients describe the procedure as far more comfortable than they expected. A topical numbing cream is applied 20 minutes before the injection, followed by a local anesthetic (lidocaine) injected directly into the treatment area. The PRF injection itself uses a fine-gauge needle and takes under five minutes per site. Patients typically report feeling only mild pressure. The blood draw from the arm is identical to a routine lab test.
Results from vaginal PRF injections typically last 12 to 18 months. The collagen remodeling and neovascularization stimulated by PRF are gradual biological processes — initial changes appear around 3–4 weeks, with full results at 2–3 months. Many patients choose to return for an annual maintenance treatment to sustain their results. Individual outcomes vary based on age, health, and the specific area treated.
The procedure is sometimes marketed elsewhere as the “O-Shot,” a branded term Dr. Akhavan does not use because it trivializes what is a genuine medical procedure with real regenerative science behind it. The clinical technique — injecting autologous platelet concentrate into vaginal and vulvar tissue — is the same concept, but The Dermatology and Laser Group uses PRF rather than standard PRP, which offers a significantly higher growth factor concentration and sustained release. More importantly, every injection here is performed by a board-certified dermatologist, not delegated to non-physician staff.
This procedure is not recommended for patients who are currently pregnant, have an active infection in the treatment area (such as an active herpes outbreak or bacterial vaginosis), have a bleeding disorder or are on anticoagulant therapy that cannot be paused, or have a platelet disorder that would compromise the quality of the PRF concentrate. Patients with a history of gynecological cancer should consult their oncologist before proceeding. Dr. Akhavan evaluates candidacy on a case-by-case basis during the consultation.
Yes. Patients frequently combine vaginal PRF injections with other treatments offered at The Dermatology and Laser Group. ThermiVa — a radiofrequency-based vaginal tightening treatment — is the most common complement, as it addresses external tissue laxity while PRF addresses internal regeneration and sensitivity. Some patients also combine the Vampire Wing Lift (labia majora PRF) with labial puff hyaluronic acid filler for additional volume. Dr. Arash Akhavan creates combination protocols tailored to each patient’s anatomy and goals.
Some patients see meaningful results from a single treatment session. However, a series of four sessions spaced 4 weeks apart is our standard recommendation with all PRP/PRF procedures for maximum benefits. Dr. Akhavan discusses the optimal treatment plan during the consultation based on the patient’s specific concerns and goals.
There is effectively no recovery period. Patients leave the office and return to their normal activities — including work — the same day. Mild swelling or tenderness at the injection site is common for 24–48 hours. Sexual activity can typically be resumed within 24–48 hours, though individual recommendations may vary. There are no stitches, no bandaging, and no activity restrictions beyond what Dr. Akhavan discusses during the appointment.
Our Manhattan Address for Intimate Wellness
The Dermatology and Laser Group is located at 110 East 60th Street on Manhattan's Upper East Side — a dedicated medical dermatology practice steps from Park Avenue. Unlike many med spas, every vaginal PRF treatment here takes place in a clinical setting under the direct care of a board-certified dermatologist. Whether you are coming from Lenox Hill, Sutton Place, Midtown East, or Central Park South, the office is easily accessible by subway. For patients traveling from outside Manhattan, our location is a short cab ride from Penn Station or Grand Central Terminal — making The Dermatology and Laser Group a convenient choice for vaginal PRP and PRF injections in New York City.
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Arash Akhavan, MD is founder and owner of The Dermatology and Laser Group, one of the top centers for cosmetic procedures in New York City for over a decade. Arash Akhavan, MD, FAAD is a Board Certified Dermatologist and an Associate Professor at The Mount Sinai School of Medicine. Dr. Akhavan is a Castle Connolly Top Doc, New York Magazine Best Doctor, and Super Doctor featured in The New York Times. Dr. Akhavan is a key opinion leader that has been featured on hundreds of media publications including The New York Times, Allure, Marie Claire, Women’s Health, Cosmopolitan, ABC News, Fox News, Fox 5, NY1, WPIX, and more. He has been featured on nationally syndicated television programs such as The Doctors.
Dr. Akhavan serves as an educator and lecturer for multiple aesthetic device and injectable companies. This allows his office access to newer technologies at an earlier date than other offices, as well as a higher level of expertise in the use of these devices. This, in turn, translates to more effective and safer treatments for our patients.