Botox vs. Xeomin: An In-Depth Comparison

In recent years, cosmetic treatments for reducing the appearance of fine lines and wrinkles have become increasingly popular. Two of the most well-known treatments in this category are Botox and Xeomin. In this comprehensive guide, we will explore the differences and similarities between Xeomin and Botox, as well as the advantages and disadvantages of each anti aging treatment.

What is Botox Cosmetic?

Botox, or botulinum toxin type A, is a purified protein derived from the bacterium Clostridium botulinum. It was first approved by the FDA in 2002 for the treatment of moderate to severe frown lines between the eyebrows (called glabellar lines). Since then, its uses have expanded to include the treatment of forehead wrinkles, crow’s feet, and other cosmetic concerns, as well as various medical conditions like hyperhidrosis, overactive bladder, and muscle spasms.

Common uses for Botox

Botox works by blocking nerve signals to the targeted muscles, causing them to relax and reducing the appearance of wrinkles. Botox treatments are most commonly used to:

• Treat frown lines between the eyebrows
• Reduce forehead lines and wrinkles
• Minimize crow’s feet around the eyes
• Address excessive sweating (hyperhidrosis)

What is Xeomin?

Xeomin, like Botox, is a form of botulinum toxin type A. It was approved by the FDA in 2011 for the treatment of glabellar lines, making it a relatively newer option in the world of injectable treatments. The primary difference between Xeomin and Botox lies in their formulation: Xeomin is considered a “naked injectable” because it does not contain any accessory proteins, whereas Botox does. This difference in formulation may have implications in terms of efficacy and the development of antibodies.

Common uses for Xeomin

Xeomin is used to treat similar cosmetic concerns as Botox, including:

• Treating frown lines between the eyebrows
• Addressing forehead lines and wrinkles
• Reducing crow’s feet around the eyes
• Treating cervical dystonia and other muscle-related conditions

Chemical Structure of Botox and Xeomin

Botulinum Toxin: The Active Ingredient

Both Botox and Xeomin contain botulinum toxin type A as their active ingredient. This neurotoxin is responsible for relaxing the targeted muscle groups and reducing the appearance of lines and wrinkles.

Purified Form and Accessory Proteins

The main difference between Xeomin and Botox is in their formulation. Botox contains accessory proteins in addition to the botulinum toxin, while Xeomin is a “naked injectable” containing only the purified botulinum toxin. This distinction may impact the development of antibodies and the overall effectiveness of each treatment, although both products have been shown to be effective in clinical trials.

Efficacy: Botox vs. Xeomin

Treating Lines and Wrinkles

When it comes to treating lines and wrinkles, both have been shown to produce similar results. Several clinical trials have demonstrated that the efficacy of Xeomin is comparable to that of Botox. However, individual responses to each treatment may vary, and some patients may prefer one product over the other based on their personal experience.

Duration of Results

The duration of results for both products is generally comparable, with most patients experiencing the effects of the treatment for up to six months. It is important to note that individual results may vary, and the duration of the effects can depend on factors such as the patient’s age, skin type, and the area being treated. Regular maintenance treatments are typically recommended to maintain the desired results.

Safety and Side Effects

FDA Approval and Medical Conditions

Both Botox and Xeomin have received FDA approval for the treatment of frown lines, as well as other medical conditions. Botox has a longer history of FDA-approved uses, while Xeomin has been approved for a smaller number of indications. However, both treatments have been proven safe and effective when administered by a trained professional.

Botox: FDA Approved Uses

• Glabellar lines
• Crow’s feet
• Forehead lines
• Excessive sweating (hyperhidrosis)
• Overactive bladder
• Muscle spasms

Xeomin: FDA Approved Uses

• Glabellar lines
• Cervical dystonia
• Blepharospasm (uncontrollable eye twitching)
• Excessive drooling (sialorrhea)

Side Effects and Safety

As with any cosmetic treatment, there are potential side effects associated with Xeomin and Botox injections. The most common side effects of both treatments include:

• Injection site pain, swelling, or redness
• Headache
• Muscle weakness near the treatment area
• Dry mouth

In rare cases, patients may experience allergic reactions or difficulty breathing. It is important to discuss any medical conditions, allergies, or concerns with your healthcare provider before undergoing either a Botox or Xeomin procedure.

Which is Better: Botox or Xeomin?

Factors to Consider

When choosing between Botox vs Xeomin, several factors should be considered, including:

• Personal preference: Some patients may find that they respond better to one treatment over the other, based on their individual experience.
• Formulation: As mentioned earlier, Xeomin is a purified form of botulinum toxin, while Botox contains accessory proteins. This difference may affect the development of antibodies or the overall effectiveness of each treatment for some individuals.
• Cost: The cost of Botox and Xeomin treatments may vary depending on the provider and the area being treated. It is essential to consider your budget when choosing between these two options.

Ultimately, the choice between Xeomin and Botox should be made in consultation with a qualified medical professional who can assess your individual needs and recommend the best treatment option for you.

The Dermatology and Laser Group: Expertise in Botox and Xeomin Treatments

When seeking treatment with Botox or Xeomin, it is crucial to find a skilled and experienced provider who can deliver safe and effective results. The Dermatology and Laser Group in New York City, led by Board Certified Dermatologist Dr. Arash Akhavan, offers exceptional care and expertise in administering both Xeomin and Botox injections.

Dr. Arash Akhavan: Board Certified Dermatologist

With over 15 years of experience in Botox injections, Dr. Akhavan is highly regarded for his skill, precision, and commitment to achieving natural-looking results. He and his team at The Dermatology and Laser Group prioritize patient comfort, satisfaction, and safety, ensuring that each treatment is customized to meet the unique needs and goals of every individual.

In conclusion, Xeomin and Botox are both highly effective treatments for reducing the appearance of lines and wrinkles. While there are some differences in their formulations, the overall results are quite similar, and the best choice will ultimately depend on individual factors and preferences.

By working with a qualified and experienced provider like Dr. Arash Akhavan at The Dermatology and Laser Group, you can trust that you will receive the highest level of care and achieve your desired cosmetic goals. To learn more about Botox and Xeomin treatments or to schedule a consultation with Dr. Akhavan, please visit The Dermatology and Laser Group website.

Frequently Asked Questions

What is Botox?

Botox is a cosmetic procedure that utilizes a purified form of botulinum toxin type A to temporarily reduce the appearance of fine lines and wrinkles. The active ingredient in Botox works by blocking nerve signals to the targeted facial muscles, causing them to relax and reducing the appearance of dynamic wrinkles.

What is Xeomin?

Xeomin is also a cosmetic procedure that utilizes a purified form of botulinum toxin type A to temporarily reduce the appearance of lines and wrinkles. Unlike Botox, Xeomin does not contain accessory proteins and is formulated with only the active ingredient.

How do Botox and Xeomin treatments work?

Both Xeomin and Botox work by temporarily relaxing targeted facial muscles, which reduces the appearance of fine lines and wrinkles. The active ingredient in both treatments, blocks nerve signals to the targeted muscles, causing them to relax and reducing muscle contractions that lead to the formation of dynamic wrinkles.

What are frown lines and how can they be treated with Botox or Xeomin?

Frown lines, also known as glabellar lines, are vertical lines that form between the eyebrows when the muscles in that area contract. Botox and Xeomin can be used to relax the targeted muscle groups and reduce the appearance of these lines.

What is the difference between Botox and Xeomin?

The primary difference between Xeomin and Botox is in their formulations. Botox contains accessory proteins, while Xeomin is a purified form of botulinum toxin type A. This difference may affect the development of antibodies or the overall effectiveness of each treatment for some individuals.

Are Botox and Xeomin treatments safe?

Both Botox and Xeomin have been FDA cleared and are generally considered safe when administered by a trained medical professional. As with any cosmetic treatment, there are potential side effects associated with both treatments, including injection site pain, swelling, or redness, headache, muscle weakness near the treatment area, and dry mouth. In rare cases, patients may experience an allergic reaction or difficulty breathing.

How long do Botox and Xeomin treatments last?

The duration of Xeomin and Botox treatments can vary depending on several factors, including the patient’s age, skin type, and the area being treated. In general, the effects of Botox and Xeomin treatments can last anywhere from three to six months.

What medical conditions are Botox and Xeomin approved to treat?

Both Xeomin and Botox have been FDA cleared for the treatment of glabellar lines, as well as other medical conditions. Botox has a longer history of FDA-approved uses, while Xeomin has been approved for a smaller number of indications. However, both treatments have been proven safe and effective when administered by a trained professional.

How much do Botox and Xeomin treatments cost?

The cost of Botox and Xeomin treatments may vary depending on the provider and the area being treated. It is essential to consider your budget when choosing between these two options.

How can I find a qualified medical professional to administer Botox or Xeomin treatments?

When seeking treatment with Botox or Xeomin, it is crucial to find a skilled and experienced provider who can deliver safe and effective results. The Dermatology and Laser Group in New York City, led by Board Certified Dermatologist Dr. Arash Akhavan, offers exceptional care and expertise in administering both Xeomin and Botox injections.

Can Botox or Xeomin treatments be used to treat excessive sweating?

Yes, both Xeomin and Botox have been approved by the FDA for the treatment of excessive sweating, a condition also known as hyperhidrosis. The active ingredient in both treatments works by blocking the nerve signals that trigger excessive sweating, leading to a reduction in sweat production.

What are the most common side effects associated with Botox and Xeomin treatments?

The most common side effects associated with Botox and Xeomin treatments include injection site pain, swelling, or redness, headache, and muscle weakness near the treatment area. In rare cases, patients may experience allergic reactions or difficulty breathing.

Can Botox and Xeomin treatments be combined with other cosmetic procedures?

Yes, both Botox and Xeomin treatments can be combined with other cosmetic procedures, such as dermal fillers or plastic surgery, to achieve a more comprehensive and long-lasting cosmetic outcome.

How many units of Botox or Xeomin will I need for my treatment?

The number of units of Xeomin or Botox needed for a treatment can vary depending on several factors, including the area being treated and the severity of the condition. During your consultation with a medical professional, they will assess your needs and recommend the appropriate number of units to achieve your desired outcome.

Can I develop antibodies to Botox or Xeomin?

It is possible to develop antibodies to Xeomin or Botox over time, which may impact the effectiveness of the treatment. However, the risk of developing antibodies is relatively low, and many patients can continue to receive safe and effective treatment with either product.

Can Botox or Xeomin treatments be used off-label?

Yes, both Botox and Xeomin treatments can be used off-label to treat a variety of conditions that have not received FDA clearance. However, it is important to discuss the risks and benefits of off-label use with a trained medical professional before undergoing treatment.

Can Botox or Xeomin treatments cause difficulty breathing?

In rare cases, patients may experience difficulty breathing following Botox or Xeomin treatments. This can occur when the treatment affects the muscles responsible for breathing. If you experience difficulty breathing after treatment, seek medical attention immediately.

Can Botox or Xeomin treatments be used to treat neck pain?

Yes, Xeomin and Botox treatments have been shown to be effective in treating neck pain associated with cervical dystonia, a condition characterized by involuntary muscle contractions in the neck.

Can Botox or Xeomin treatments be used to treat fine lines and wrinkles?

Yes, both Botox and Xeomin treatments can be used to treat lines and wrinkles, particularly those caused by repeated muscle contractions. These treatments can be effective in reducing the appearance of dynamic wrinkles and helping patients achieve a more youthful appearance.

Can Botox or Xeomin treatments be used to treat excessive drooling?

Yes, both Botox and Xeomin treatments have been approved by the FDA for the treatment of excessive drooling, a condition also known as sialorrhea. The active ingredient in both treatments works by blocking the nerve signals that trigger excessive saliva production.

What are the most important factors to consider when choosing between Xeomin and Botox treatments?

When considering Botox vs. Xeomin, it is important to consider several factors, including the formulation of the product, the overall efficacy and safety of the treatment, and the experience and expertise of the medical professional administering the treatment. It is also important to consider any individual preferences or medical conditions that may impact treatment outcomes.

Is it safe to mix Botox and Xeomin treatments?

While it is technically possible to mix Botox and Xeomin treatments, there is no evidence to suggest that this practice leads to better outcomes. In fact, there may be a higher risk of developing antibodies to the active ingredient if both products are used together. It is best to discuss your treatment options with a trained medical professional before deciding on a course of action.

Can Botox or Xeomin treatments be used to treat all types of wrinkles?

Xeomin and Botox treatments are most effective at treating dynamic wrinkles, which are wrinkles caused by repeated muscle contractions. However, these treatments may not be as effective at treating static wrinkles, which are wrinkles that are present even when the muscles are at rest. In these cases, other treatments, such as dermal fillers or plastic surgery, may be more appropriate.

How can I prepare for my Botox or Xeomin treatment?

Before your Botox or Xeomin appointment, it is important to avoid blood-thinning medications, such as aspirin or ibuprofen, for several days before your treatment. You should also avoid alcohol and caffeine, which can increase your risk of bruising. It is also important to discuss any medications or medical conditions you have with your provider before undergoing treatment.

How long does it take to see the results of a Botox or Xeomin treatment?

The results of a Botox or Xeomin treatment can be seen within a few days of the procedure, with full results becoming visible within a week or two. However, the duration and extent of the results can vary depending on several factors, including the area being treated and the individual patient’s response to the treatment.

Are there any medical conditions that may prevent me from receiving Botox or Xeomin treatments?

While Botox and Xeomin treatments are generally considered safe for most patients, there are some medical conditions that may prevent you from undergoing treatment. These conditions may include pregnancy or breastfeeding, a history of allergies or sensitivity to botulinum toxin, and certain neuromuscular disorders. It is important to discuss your medical history with your provider before undergoing treatment.

How can I find the best provider for my Botox or Xeomin treatment?

When seeking a provider for your Botox or Xeomin treatment, it is important to choose a qualified and experienced professional who can deliver safe and effective results. Board Certified Dermatologist Dr. Arash Akhavan at The NYC Dermatology and Laser Group is one of the best providers for Botox and Xeomin treatments, with over 15 years of experience and a commitment to exceptional patient care.

By Arash Akhavan, MD, FAAD | June 14th, 2023 | Categories: Surgical Dermatology