Daxxify in NYC: The Longer-Lasting Wrinkle Relaxer
Smooth Lines for Up to Six Months — With Fewer Visits Per Year
Why NYC's Most Discerning Patients Are Choosing Daxxify
Longer-Lasting Results, Fewer Appointments, Expert Precision
Medically reviewed by Arash Akhavan, MD, FAAD | Board-Certified Dermatologist | Founder, The Dermatology and Laser Group, New York City | Faculty, Mount Sinai Department of Dermatology
Last Medically Reviewed: March 13, 2026
Daxxify (daxibotulinumtoxinA-lanm) is the first and only peptide-formulated neuromodulator approved by the FDA — a genuine step forward from traditional wrinkle relaxers like Botox, Dysport, and Xeomin. At The Dermatology and Laser Group on Manhattan's Upper East Side, every Daxxify treatment is performed personally by Dr. Arash Akhavan, one of the first physicians in New York City to earn the Revance Guru designation many years ago — an elite distinction given to injectors who train other providers on proper Daxxify technique, as well as dermal fillers.
What makes Daxxify different from other neuromodulators:
- Longer duration — results lasting up to 6 months, with some patients experiencing improvement for up to 9 months
- Faster onset — visible smoothing in as little as 1–2 days compared to 10–14 days with Botox
- No human or animal byproducts — Daxxify's proprietary peptide technology means a cleaner, vegan-friendly formulation
- Fewer office visits per year — most patients need only 2 treatments annually instead of 3–4
Arash Akhavan, MD, FAAD — a board-certified dermatologist, Castle Connolly Top Doctor for over 13 consecutive years, and Assistant Clinical Professor of Dermatology at Mount Sinai — brings over a decade of injectable neuromodulator expertise to every treatment. Whether you are considering Daxxify in Manhattan for the first time or switching from Botox, Dr. Arash Akhavan and the team deliver the natural, refined results that luxury patients expect.
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The Science Behind the Peptide-Powered Wrinkle Relaxer
Daxxify is the newest FDA-approved wrinkle relaxer on the market, approved in September 2022, and it is fundamentally changing the experience for patients who want longer-lasting results without more frequent appointments. It treats the same frown lines, forehead wrinkles, and crow's feet that Botox addresses, but with one meaningful advantage: results that can last up to 6 months instead of the typical 3 to 4.
"The moment Daxxify became available, I knew it would change how we approach neuromodulators in our practice," says Dr. Arash Akhavan. "Patients tell me all the time that the biggest inconvenience of Botox was having to come in every three months. With Daxxify, most of my patients are coming in just twice a year for the same beautiful results."
The science behind that longer performance comes down to formulation. Unlike Botox, which is stabilized with a protein derived from human blood (human serum albumin), Daxxify uses a clean, lab-engineered synthetic peptide. That means no human or animal byproducts — and a formulation that adheres to the muscle receptor longer, keeping results in place well beyond what traditional neuromodulators deliver.
At The Dermatology and Laser Group, Arash Akhavan, MD, FAAD uses his expertise as a certified Revance Guru to customize every Daxxify treatment to each patient's unique facial anatomy. The goal is always natural movement, balanced results, and the kind of subtle refinement that his patients on the Upper East Side expect.
How Daxxify and Botox Compare
Both Daxxify and Botox are botulinum toxin type A products that work by temporarily blocking acetylcholine release at the neuromuscular junction, relaxing targeted muscles to smooth dynamic wrinkles. But there are meaningful clinical differences that matter when choosing between them.
Duration of results: Botox typically lasts 3–4 months, requiring 3–4 treatment sessions per year. Daxxify has a median duration of 6 months, with results lasting up to 9 months in some patients — meaning most patients need only 2 appointments per year.
Speed of onset: Botox takes approximately 10–14 days to reach full effect. Daxxify can show visible results in as little as 1–2 days — a meaningful difference for patients with upcoming events or simply those who want to see their results sooner.
Formulation: Botox is stabilized with human serum albumin. Daxxify uses a synthetic peptide stabilizer — no human or animal byproducts, making it the only vegan neuromodulator on the market.
Clinical efficacy: Both products achieve similar peak efficacy. FDA data from the SAKURA clinical trials showed that 74% of Daxxify patients achieved a 2-grade or greater improvement in frown lines at week 4. The primary differentiator is how long those results last.
"I offer Botox, Daxxify, and Xeomin at our practice, but at this point 99.9% of our patients prefer Daxxify," says Arash Akhavan, MD. "With the same effects, matched with quicker onset and longer duration of action, it has simply become the better product for almost everyone."
Treatment Areas and What Daxxify Can Address
What Daxxify Can Treat at Our NYC Practice
While Daxxify is FDA-approved specifically for moderate to severe glabellar lines (frown lines between the brows), Dr. Arash Akhavan also uses it with expert precision to address a broader range of facial concerns at The Dermatology and Laser Group.
Treatment areas include:
- Glabellar lines ("the 11s") — the vertical frown lines between the eyebrows; Daxxify's FDA-approved indication and where it truly excels
- Forehead lines — horizontal lines that appear when raising the brows, softened while preserving natural expression
- Crow's feet — fine lines that radiate from the outer corners of the eyes during smiling
- Brow lift — strategic micro-dosing along the brow to create a subtle, natural lift
- Bunny lines — creases that form on the nose when scrunching or laughing
- Lip flip — relaxing the upper lip muscles for a subtle pout without filler
- Neck bands (platysmal bands) — smoothing prominent vertical cords in the neck
- Masseter reduction / jawline slimming — relaxing the jaw muscles for a softer, more tapered jawline
Key benefits of choosing Daxxify at The Dermatology and Laser Group:
- Extended results — up to 6 months means fewer office visits and more time enjoying smooth skin
- Rapid onset — see smoothing in 1–2 days, ideal for patients with upcoming events
- Clean formulation — no human serum albumin, vegan-friendly
- Expert injector — Dr. Arash Akhavan is a certified Revance Guru who has performed thousands of neuromodulator treatments
- Precision technique — using the specialized TSK "Invisible Needle" from Japan for a near-painless injection experience
- Transparent pricing — flat-fee pricing with no per-unit surprises
This procedure is not recommended for patients who are pregnant, have a known allergy to botulinum toxin or any component of the formulation, or have an active infection at the intended injection site. Patients with certain neuromuscular conditions should discuss candidacy with Dr. Akhavan during their consultation.
Daxxify Before and After Results
Transparent Flat-Fee Pricing for Daxxify in NYC
The standard cost for Daxxify at The Dermatology and Laser Group in New York City is $750 for the first treatment area and $200 for each additional area. Daxxify is priced the same as Botox at our practice — a significant advantage for patients interested in the longer-lasting option.
Dr. Arash Akhavan's practice uses a flat-fee pricing model, which eliminates the per-unit guessing game that many NYC clinics rely on. You know exactly what you will pay before your treatment begins — no surprise charges, no upsell pressure.
Many patients find that when they factor in the longer duration of Daxxify (up to 6–9 months vs. 3–4 months for Botox), the annual cost of maintaining Daxxify is comparable to or lower than a traditional Botox regimen, since you may need only 2 treatments per year instead of 3–4.
"I hear from new patients all the time who are frustrated by the per-unit pricing model at other offices," says Arash Akhavan, MD, FAAD. "They never know what their bill will be until they are sitting in the chair. Our flat-fee approach means the price is the price — and every injection is performed by me personally, not a nurse or PA."
Every Daxxify treatment in Manhattan at our practice is performed personally by a board-certified dermatologist, Castle Connolly Top Doctor, and certified Revance Guru who has invested years in mastering injectable neuromodulators.
Patient Testimonials and Reviews
Comparing Today's FDA-Approved Neuromodulators
There are currently four FDA-approved botulinum toxin type A neuromodulators available in the United States: Daxxify, Botox, Dysport, and Xeomin. Each works by temporarily blocking acetylcholine release at the neuromuscular junction, but they differ in formulation, onset, and duration. The table below presents clinical data from FDA labeling and published trials to help you make an informed decision.
| Feature | Daxxify | Botox | Dysport | Xeomin |
|---|---|---|---|---|
| FDA Approved | 2022 | 2002 | 2009 | 2010 |
| Typical Duration | Up to 6 months | 3–4 months | 3–4 months | ~3 months |
| Onset of Action | 1–2 days | 10–14 days | 2–5 days | 5–7 days |
| Treatments/Year | ~2 | 3–4 | 3–4 | 3–4 |
| Stabilizer | Synthetic peptide | Human albumin | Human albumin | None (naked) |
| Vegan Friendly | Yes | No | No | No |
| Manufacturer | Revance | Allergan | Galderma | Merz |
Frequently Asked Questions About Daxxify
Daxxify (daxibotulinumtoxinA-lanm) is an FDA-approved injectable wrinkle relaxer that uses a proprietary synthetic peptide stabilizer instead of the human serum albumin found in Botox. This innovative formulation contributes to a longer duration of action — a median of 6 months compared to Botox’s typical 3–4 months. Both products temporarily relax facial muscles to smooth dynamic wrinkles, but Daxxify’s extended results mean fewer office visits and lower annual maintenance for most patients.
Daxxify demonstrated a median duration of 6 months in the SAKURA clinical trials, with some patients experiencing results for up to 9 months. This is significantly longer than Botox (3–4 months), Dysport (3–4 months), and Xeomin (approximately 3 months). Individual results vary depending on metabolism, muscle strength, and the specific treatment area, which is why Dr. Arash Akhavan customizes every treatment plan during consultation.
Many patients notice visible smoothing within 1–2 days of treatment, compared to the 10–14 days typically required for Botox to reach full effect. This rapid onset makes Daxxify an excellent choice for patients preparing for an upcoming event or those who simply prefer seeing results sooner.
Yes. Daxxify was approved by the FDA in September 2022 after rigorous clinical testing in the SAKURA 1 and SAKURA 2 trials, which enrolled over 2,600 participants. The most common side effects are similar to other neuromodulators and include mild headache and temporary eyelid drooping — both rare when the procedure is performed by an experienced, board-certified injector like Arash Akhavan, MD.
At The Dermatology and Laser Group, Daxxify is priced at $750 for the first treatment area and $200 for each additional area — the same as our Botox pricing. Because Daxxify lasts approximately twice as long as Botox, many patients find the annual cost is comparable or even lower when factoring in fewer required appointments per year.
Absolutely — and almost all of our patients have made the switch. Dr. Arash Akhavan recommends waiting until your current Botox treatment has fully worn off before trying Daxxify for the first time. During your consultation, he will evaluate your facial anatomy and treatment history to create a seamless transition plan.
Daxxify is appropriate for healthy adults who want to smooth moderate to severe frown lines, forehead lines, crow’s feet, or other dynamic wrinkles. It is particularly popular among patients who want longer-lasting results with fewer office visits, those who prefer a vegan and human-albumin-free formulation, and patients who have used Botox or Dysport previously and are looking for an upgrade. This treatment is not recommended for patients who are pregnant, have a known allergy to botulinum toxin, or have certain neuromuscular conditions. Dr. Arash Akhavan evaluates every patient individually during a consultation at our Upper East Side office.
No. Unlike Botox, which is stabilized with human serum albumin derived from human blood, Daxxify uses a synthetic peptide stabilizer. This makes Daxxify the only neuromodulator on the market that is free of human and animal byproducts — a feature that appeals to many patients in New York City seeking a cleaner, vegan-friendly option.
Your appointment begins with a consultation with Dr. Arash Akhavan, who assesses your facial anatomy and discusses your aesthetic goals. The injection itself takes approximately 10–15 minutes. The practice uses the specialized TSK “Invisible Needle” from Japan for a near-painless experience. There is no downtime — you can return to your normal activities immediately, and most patients begin to see results within 1–2 days.
The Dermatology and Laser Group is located at 110 East 60th Street, Suite 606, on Manhattan’s Upper East Side — easily accessible from Midtown East, Midtown, Lenox Hill, Sutton Place, and Central Park South. Arash Akhavan, MD, FAAD is one of the first Revance Guru-certified injectors in NYC, making this practice one of the top destinations for Daxxify in New York City. To schedule a consultation, call 212-444-8204 or visit our online booking page.
A Premier Upper East Side Address for Refined Aesthetics
The Dermatology and Laser Group is located at 110 East 60th Street, just off Park Avenue on Manhattan’s Upper East Side — a discreet, luxury medical environment that our Daxxify patients appreciate from the moment they walk through the door. The office is easily accessible from Midtown East, Lenox Hill, Sutton Place, Central Park South, and the greater Midtown corridor, whether you are coming from your office on Fifth Avenue or your home uptown. Our location in the heart of one of New York City’s most prestigious neighborhoods reflects the premium, expert-level care that defines every visit.
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